Na prvoj stranici dnevnog lista La Repubblica piše 'Veronica: Zbogom Silvio, odlučila sam, tražim rastavu'.
Reports that Silvio Berlusconi's wife Veronica wants a divorce surfaced in the country's Sunday newspapers.
The couple married in 1990 and have three children, along with two from the charismatic politician's first marriage.
Veronica is quoted by one newspaper saying she had been "forced to take this step."
It comes days after the 52-year-old publicly criticised her husband's party's selection of young female candidates for the European elections.
She also criticised him for going to the 18th birthday party of the daughter of a political acquaintance.
Veronica told an Italian news agency Berlusconi hadn't attended his own children's coming-of-age parties.
The prime minister's office has declined to comment on the reports.
Now 72, the media tycoon is in his third spell as premier.
Jim Drury, Reuters